Mapping aggregation-specific interactions in human disease

Newest publications

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  FoldDelay web server: an online tool to quantify translation-driven delays in protein native contact formation

  Ramon Duran‑Romaña, Joost Schymkowitz, Frederic Rousseau

  Nucleic Acids Res . 2026 Apr 28

  PubMed
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  Atomic structures of medin and Aβ fibrils reveal polymorphic remodeling in mixed amyloid systems

  Brajabandhu Pradhan, Senthil T Kumar, Jessica Wagner, Rodrigo Gallardo, Gabriele Orlando, Matthias De Vleeschouwer, Valentina Zorzini, Jillian Madine, Nikolaos Louros, Jonas J Neher, Frederic Rousseau, Joost Schymkowitz

  Nat Commun . 2026 Apr 28.

  PubMed
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  Belgian recommendations for tissue diagnosis of amyloidosis

  Amélie Dendooven, Annelore Vandendriessche, Priyanka Joseph Koshy, Frank Timmermans, Marijn Speeckaert, Nicolas Kint, Lucas Van Aelst, Marie‑Christiane Vekemans, Nathalie Meuleman, Anne‑Catherine Pouleur, Antoine Bondue, Steven Droogmans, Philippe Debonnaire, Jan De Bleecker, Amaryllis Van Craenenbroeck, Rodrigo Gallardo, Joost Schymkowitz, Frédéric Rousseau, Francis Impens, Simon Devos, Michel Delforge

  Acta Clin Belg . 2026

  PubMed
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  Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity

  Katerina Konstantoulea, Meine Ramakers, Sarah C. Borrie, Dries T’Syen, Daan Moechars, Malgorzata A. Sliwinska, Brajabandhu Pradhan, Giulia Albertini, Nóra Baligács, Grigoria Tsaka, Bert Houben, Mark Fiers, Rodrigo Gallardo, Maarten Dewilde, Dietmar Rudolf Thal, Michael Willem, Jonas J. Neher, Bart De Strooper, Frederic Rousseau, Joost Schymkowitz

  Proc Natl Acad Sci US 2026 Mar 10

  PubMed
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  Conformation-specific monoclonal antibodies reveal early Tau structural intermediates in Alzheimer's disease

  Grigoria Tsaka, Aida Montserrat Pagès, Cristiano Brás De Sousa, Jeroen Lammertyn, Grzegorz Walkiewic, Luis Aragão Gomes, Maya Imbrechts, Sophie Tops, Rajasekhar Kolla, Kevin Muwonge, Rik Vandenberghe, Karen Vanhoorelbeke, Christine A F von Arnim, Nick Geukens, Frederic Rousseau, Joost Schymkowitz, Dragana Spasic, Dietmar Rudolf Thal, Debby Thomas, Joris Winderickx

  J Biol Chem . 2026 Feb 3

  PubMed
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  In silico design of stable single-domain antibodies with high affinity

  Zhongyao Zhang, Rob van der Kant, Iva Marković, David Vizarraga, Teresa Garcia, Katerina Maragkou, Javier Delgado Blanco, Damiano Cianferoni, Gabriele Orlando, Gabriel Cia, Nick Geukens, Carlo Carolis, Alexander N Volkov, Savvas N Savvides, Maarten Dewilde, Joost Schymkowitz, Luis Serrano Pubul, Frederic Rousseau

  Structure . 2026 Jan 9

  PubMed