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CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods
CAGI community
Genome Biol . 2024 Feb
PubMedLocal structural preferences in shaping tau amyloid polymorphism
Nikolaos Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowitz
Nat Commun . 2024 Feb 3
PubMedLRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons
Baptiste Libé-Philippot, Amélie Lejeune, Keimpe Wierda, Nikolaos Louros, Emir Erkol, Ine Vlaeminck, Sofie Beckers, Vaiva Gaspariunaite, Angéline Bilheu, Katerina Konstantoulea, Hajnalka Nyitrai, Matthias De Vleeschouwer, Kristel M Vennekens, Niels Vidal, Thomas W Bird, Daniela C Soto, Tom Jaspers, Maarten Dewilde, Megan Y Dennis, Frederic Rousseau, Davide Comoletti, Joost Schymkowitz, Tom Theys, Joris de Wit, Pierre Vanderhaeghen
Cell . 2023 Dec 21
PubMedN-glycosylation as a eukaryotic protective mechanism against protein aggregation
Ramon Duran-Romaña, Bert Houben, Matthias De Vleeschouwer, Nikolaos Louros, Matthew P Wilson, Gert Matthijs, Joost Schymkowitz, Frederic Rousseau
Sci Adv . 2024 Feb 2
PubMedTDP-43 pathology is associated with increased tau burdens and seeding
Sandra O Tomé, Grigoria Tsaka, Alicja Ronisz, Simona Ospitalieri, Klara Gawor, Luis Aragão Gomes, Markus Otto, Christine A F von Arnim, Philip Van Damme, Ludo Van Den Bosch, Estifanos Ghebremedhin, Celeste Laureyssen, Kristel Sleegers, Rik Vandenberghe, Frederic Rousseau , Joost Schymkowitz, Dietmar Rudolf Thal
Mol Neurodegener . 2023 Sep 30
PubMedExploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding
Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere , Frederic Rousseau, Joost Schymkowitz
Nat Commun Sept 2023
PubMed