Welcome to the Switch Laboratory

Mapping aggregation-specific interactions in human disease

Our research focuses on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease. In particular, we are investigating how protein aggregation affects the interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions. These latter are especially relevant as they are usually associated with gain of function activities such as neurotoxicity (neurodegeneration).

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Newest publications

  • publication

    CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

    CAGI community
    Genome Biol . 2024 Feb
    PubMed
  • publication

    Local structural preferences in shaping tau amyloid polymorphism

    Nikolaos Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowitz
    Nat Commun . 2024 Feb 3
    PubMed
  • publication

    LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons

    Baptiste Libé-Philippot, Amélie Lejeune, Keimpe Wierda, Nikolaos Louros, Emir Erkol, Ine Vlaeminck, Sofie Beckers, Vaiva Gaspariunaite, Angéline Bilheu, Katerina Konstantoulea, Hajnalka Nyitrai, Matthias De Vleeschouwer, Kristel M Vennekens, Niels Vidal, Thomas W Bird, Daniela C Soto, Tom Jaspers, Maarten Dewilde, Megan Y Dennis, Frederic Rousseau, Davide Comoletti, Joost Schymkowitz, Tom Theys, Joris de Wit, Pierre Vanderhaeghen
    Cell . 2023 Dec 21
    PubMed
  • publication

    N-glycosylation as a eukaryotic protective mechanism against protein aggregation

    Ramon Duran-Romaña, Bert Houben, Matthias De Vleeschouwer, Nikolaos Louros, Matthew P Wilson, Gert Matthijs, Joost Schymkowitz, Frederic Rousseau
    Sci Adv . 2024 Feb 2
    PubMed
  • publication

    TDP-43 pathology is associated with increased tau burdens and seeding

    Sandra O Tomé, Grigoria Tsaka, Alicja Ronisz, Simona Ospitalieri, Klara Gawor, Luis Aragão Gomes, Markus Otto, Christine A F von Arnim, Philip Van Damme, Ludo Van Den Bosch, Estifanos Ghebremedhin, Celeste Laureyssen, Kristel Sleegers, Rik Vandenberghe, Frederic Rousseau , Joost Schymkowitz, Dietmar Rudolf Thal
    Mol Neurodegener . 2023 Sep 30
    PubMed
  • publication

    Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

    Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere , Frederic Rousseau, Joost Schymkowitz
    Nat Commun Sept 2023
    PubMed